▶ Manufacturer: Ilhwa Co., Ltd.
▶ Sold by: Ilhwa Co., Ltd.
▶ Insurance code : 640900280
▶ Storage : Dark, airtight container, store at room temperature (1 to 30℃)
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Light yellow, elliptical film-coated tablet
Hydrochlorothiazide 25mg
Adults
The usual dose of this drug is 1 tablet 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. Doses exceeding 100mg Losartan potassium / 25mg hydrochlorothiazide per day are not recommended. In general, max. hypotensive effect appears around 3 weeks after treatment. This drug may be administered together with other anti-hypertensive preparations, and may be administered regardless of meals. To minimize adverse reactions, begin administration of this drug when single therapy does not yield the expected effects.
1. Replacement therapy: Concomitant therapy of Losartan potassium and hydrochlorothiazide with adjusted doses may be replaced with this drug.
2. Patients where blood pressure is not regulated by single therapy of Losartan or hydrochlorothiazide: Begin with 1 tablet 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. If blood pressure is not regulated after 3 weeks of administration, dose may be increased up to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
3. Patients where blood pressure is not regulated by single therapy of 100mg Losartan potassium: Begin with 1 tablet 100mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. If blood pressure is not regulated after 3 weeks of administration, dose may be increased up to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
4. Patients where blood pressure is not regulated by 25mg hydrochlorothiazide once a day, or where blood pressure is regulated at this dose but with hypokalemia: Therapy may be begun with 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day, reducing hydrochlorothiazide dose while maintaining overall hypotensive effect. Continue measuring clinical response to 50mg Losartan potassium / 12.5mg hydrochlorothiazide thereafter; if blood pressure is not regulated even after 3 weeks of administration, dose may be increased to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
Patients with renal impairment
Administer the usual dose for cases where creatinine clearance rate is 30mL/min or higher. For patients with more severe renal impairment, use of loop diuretics is preferred over thiazide drugs; administration of this drug to such patients is not recommended.
Patients with liver impairment
Starting dose of 25mg Losartan potassium for liver impairment patients requiring dose adjustment cannot be administered with this drug; administration to such patients is not recommended.
Pediatrics (under 18 years of age)
No data on use in children and youth; do not administer Losartan-hydrochlorothiazide combination drug to children and youth.
Hypertension where blood pressure is not adequately regulated through single therapy
Light yellow, elliptical film-coated tablet
Hydrochlorothiazide 25mg
Adults
The usual dose of this drug is 1 tablet 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. Doses exceeding 100mg Losartan potassium / 25mg hydrochlorothiazide per day are not recommended. In general, max. hypotensive effect appears around 3 weeks after treatment. This drug may be administered together with other anti-hypertensive preparations, and may be administered regardless of meals. To minimize adverse reactions, begin administration of this drug when single therapy does not yield the expected effects.
1. Replacement therapy: Concomitant therapy of Losartan potassium and hydrochlorothiazide with adjusted doses may be replaced with this drug.
2. Patients where blood pressure is not regulated by single therapy of Losartan or hydrochlorothiazide: Begin with 1 tablet 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. If blood pressure is not regulated after 3 weeks of administration, dose may be increased up to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
3. Patients where blood pressure is not regulated by single therapy of 100mg Losartan potassium: Begin with 1 tablet 100mg Losartan potassium / 12.5mg hydrochlorothiazide once a day. If blood pressure is not regulated after 3 weeks of administration, dose may be increased up to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
4. Patients where blood pressure is not regulated by 25mg hydrochlorothiazide once a day, or where blood pressure is regulated at this dose but with hypokalemia: Therapy may be begun with 50mg Losartan potassium / 12.5mg hydrochlorothiazide once a day, reducing hydrochlorothiazide dose while maintaining overall hypotensive effect. Continue measuring clinical response to 50mg Losartan potassium / 12.5mg hydrochlorothiazide thereafter; if blood pressure is not regulated even after 3 weeks of administration, dose may be increased to 100mg Losartan potassium / 25mg hydrochlorothiazide once a day.
Patients with renal impairment
Administer the usual dose for cases where creatinine clearance rate is 30mL/min or higher. For patients with more severe renal impairment, use of loop diuretics is preferred over thiazide drugs; administration of this drug to such patients is not recommended.
Patients with liver impairment
Starting dose of 25mg Losartan potassium for liver impairment patients requiring dose adjustment cannot be administered with this drug; administration to such patients is not recommended.
Pediatrics (under 18 years of age)
No data on use in children and youth; do not administer Losartan-hydrochlorothiazide combination drug to children and youth.
Hypertension where blood pressure is not adequately regulated through single therapy